The upcoming San Diego FC vs St. Louis matchup is drawing attention across Major League Soccer. Both teams are looking to make a statement in the Western Conference, with San Diego FC aiming to build on their impressive start while St. Louis City SC seeks to reverse a troubling run of form.

Key Details: Match Time and Setting

The San Diego FC vs St. Louis battle unfolds at Energizer Park on Saturday, May 10, with kickoff set for 7:30 p.m. CT. St. Louis CITY SC will enjoy home advantage and hope to harness the support of their fans to overcome a persistent winless streak (official match preview).

Recent Form: Contrasting Momentum

St. Louis City SC comes into this game desperate for a turnaround. Their last seven matches have produced no wins—a tough stretch by any measure. Their most recent outing in MLS ended in a 4-1 defeat at Seattle. However, a midweek U.S. Open Cup win against Union Omaha has offered a glimmer of hope. Coach Olof Mellberg urges his team to work harder on the pitch and find creative solutions in attack. St. Louis remains 13th in the standings and is searching for consistency at both ends of the field. For additional background on their struggles and needed improvements, read the full local analysis.

In contrast, San Diego FC is experiencing early success in its debut season. Sitting fourth in the conference standings, they recently thrashed FC Dallas 5-0, marking the largest win in the club’s young history. Key players Hirving Lozano and Anders Dreyer have been instrumental, with Dreyer boasting four goals and five assists in 11 matches. But San Diego faces pressure to improve on the road, currently riding a three-game away losing streak (match preview and stats).

Tactical Matchup: What to Watch For

The first meeting between these teams ended in a tense, scoreless draw at San Diego’s Snapdragon Stadium. St. Louis defended bravely, limiting San Diego to just one shot on target. Saturday’s rematch could be different given both squads’ recent changes and shifts in momentum. St. Louis may have to reshuffle their backline due to suspensions, while San Diego expects to be without midfielder Jeppe Tverskov. The clash in midfield and the performance of each team’s forwards—such as St. Louis’ Klauss and San Diego’s Dreyer—will be crucial.

Players to Watch

• Joao Klauss (St. Louis): Claimed a crucial Cup goal and remains their main attacking threat.
• Anders Dreyer (San Diego FC): A consistent scorer and creator, he is among MLS’s standout performers in 2025.
• Hirving Lozano (San Diego FC): His attacking talents were vital in their last big win.

Injuries could play a part for St. Louis, with key midfielder Alfredo Morales set to miss out due to an abductor injury.

Expert Prediction and Outlook

Given current form and team news, most analysts expect San Diego FC to edge out St. Louis, though home advantage could keep things close. A narrow 2-1 win for the visitors is a popular prediction (see full prediction and lineup details).

Where to Watch and Matchday Activities

Fans can stream the match live via MLS Season Pass on Apple TV. Both English and Spanish radio commentary are available for local supporters. For those attending, gates open early with matchday festivities and post-match events planned at Energizer Park. For a run-down of activities and ticket details, check the official club preview.

Final Thoughts

The San Diego FC vs St. Louis matchup promises high stakes and dramatic moments. With both clubs seeking key points, fans can expect a fiercely contested encounter. Will St. Louis break their tough run, or will San Diego build on their historic start? Don’t miss this crucial Western Conference clash.