The rivalry between the Milwaukee Brewers and the St. Louis Cardinals is always a highlight on the MLB calendar. As the Brewers hit the road to face the Cardinals for the first time this season, both teams look to solidify their positions in a competitive NL Central. Here’s everything fans need to know ahead of the exciting Brewers vs Cardinals series, including pitching matchups, player notes, and where to watch the games.

Series Overview

Both the Brewers and Cardinals aim to rebound from recent tough stretches as they clash in St. Louis. According to Brew Crew Ball’s preview, the Brewers are looking to shake off a rough series against the Giants. Meanwhile, the Cardinals are eager to reverse their fortunes after a string of losses. Despite early hurdles, a strong showing in this Brewers vs Cardinals showdown could spark a turnaround for either club.

Key Pitching Matchups

Friday, April 25

Chad Patrick (Brewers) vs. Matthew Liberatore (Cardinals)

• Patrick, coming off the first loss of his career, boasts a 2.11 ERA and impressive command. Liberatore, a left-hander finding his rhythm as a starter, has a track record of quality outings against Milwaukee.

Saturday, April 26

Quinn Priester (Brewers) vs. Sonny Gray (Cardinals)

• Priester has delivered robust performances early in his Brewers tenure. Gray, with over a decade of MLB experience, is always tough at home and has pitched well against Milwaukee in previous encounters.

For a closer look at the odds, the betting lines for Saturday's game are detailed in FOX Sports’ analysis.

Sunday, April 27

Jose Quintana (Brewers) vs. Erick Fedde (Cardinals)

• Quintana has started the season strong and will face his former squad, while Fedde seeks consistency in his second year with St. Louis. Both pitchers will be crucial in the series finale.

Offense and Player Updates

Batting has seen ups and downs on both sides. For the Brewers, Brice Turang and Sal Frelick lead the lineup, while Christian Yelich’s hot streak could make a difference in this series. The Cardinals lean on Brendan Donovan’s reliable bat and the emerging power of Lars Nootbaar. Injuries on both teams have opened doors for younger players to step up, making this Brewers vs Cardinals series an opportunity to showcase new talent.

The bullpens will also play a vital role, with Abner Uribe anchoring Milwaukee's late innings and Ryan Helsley closing games for St. Louis. Each staff has had bright spots and setbacks, so managing high-leverage situations could tip the balance.

How to Watch and Listen

All three games of the Brewers vs Cardinals series will air on FanDuel Sports Wisconsin and MLB.TV (for out-of-market viewers). Brewers fans can tune in via the Brewers Radio Network for audio coverage. Make sure to check local listings so you never miss a pitch.

For a full scouting report, bullpen breakdowns, and more in-depth stats, check out the detailed series preview on Brew Crew Ball.

Series Prediction and Final Thoughts

Historically, the Brewers vs Cardinals rivalry delivers high drama and tight games. While the Cardinals have struggled recently, their home field and offensive depth make them dangerous. However, the Brewers’ improving health and strong starting pitching could give them the edge in this matchup. Expect a closely contested series, with plenty of highlights for fans of both clubs.

Don’t miss any of the action—follow your team’s progress and explore further match predictions and expert picks on FOX Sports. Whether you’re cheering for Milwaukee or St. Louis, this Brewers vs Cardinals series is poised to write another chapter in their storied NL Central rivalry.